Polar ecosystems are sensitive to climate forcing, and we often lack baselines to evaluate changes.Here we report a nearly 50-year study in which a sudden shift in the population dynamics of an ecologically important, structure-forming hexactinellid sponge, Anoxycalyx joubini was observed.This is the largest Antarctic sponge, with individuals growi
Amyotrophic lateral sclerosis (ALS) is a severe adult motor neuron Mens Jackets disease that causes progressive neuromuscular atrophy, muscle wasting, weakness, and depressive-like symptoms.Our previous research suggests that mercury levels are directly associated with ALS progression.MeHg+-induced ALS is characterised by oligodendrocyte destructio
The type VI secretion system (T6SS) mediates protein translocation across the cell membrane of Gram-negative bacteria, including Vibrio cholerae - the causative agent of cholera.All V.cholerae strains examined to date harbor gene clusters encoding a T6SS.Structural similarity and sequence homology between components of the T6SS and the T4 bacteriop
Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes.To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele combinations by genetically restricting intracellular beta-catenin expression in the correspondi
Objectives: Assess and improve advance care planning (ACP) awareness and uptake among gynecologic oncology patients.Methods: Using a quality improvement Plan-Do-Check-Act framework, we completed a single institution needs assessment and intervention.The needs assessment was a 26-question survey assessing baseline ACP knowledge and preferences of gy